Endocrine Abstracts

The critical contribution of deficient insulin secretion to the pathogenesis of type 2 diabetes is beyond doubt. The normal beta-cell response to obesity-associated insulin resistance is hypersecretion of insulin that maintains blood glucose levels within the normal range. This is associated with both expansion of beta-cell mass and enhanced beta-cell function. Type 2 diabetes only develops in subjects that are unable to sustain the beta-cell compensatory response. This is ass...